Dr. Timothy Rodwell

Timothy Rodwell MD, PhD, MPH 
Timothy Rodwell MD, PhD, MPH  is an associate professor and physician in the Division of Global Health at UCSD and an adjunct assistant professor at the Biomedical Informatics Research Center at San Diego State University.

He received his PhD from UC Davis, his MD from Stanford University and his MPH and Preventive Medicine Residency at SDSU and UCSD. He has training in medicine, infectious disease ecology, epidemiology and molecular epidemiology.

Since 1995, his work has been primarily focused on tuberculosis (TB), with an emphasis on emerging infectious disease and the molecular epidemiology of drug resistance. Dr. Rodwell recently completed a study on the binational transmission of MDR-TB (K01AI083784) and is currently the Project Director of Molecular Epidemiology for the Global Consortium for Drug-resistant TB Diagnostics (GCCD), a multinational study of the molecular basis of TB drug resistance and rapid TB diagnostics (U01AI082229). He is also currently a co-investigator on two recently funded NIH projects exploring the evolutionary and functional significance of novel mutations in drug M/XDR-TB isolates (R01AI105185) and point of care molecular diagnostics (R44EB01127403). As Project Director of Molecular Epidemiology for GCCD, he is supervising the phenotypic and molecular characterization of over 1,500 M/XDR-TB isolates collected from India, Moldova, Philippines and South Africa. He currently oversees the phenotypic drug susceptibility testing (DST), genotyping (spoligotyping/MIRU), Sanger sequencing, Whole Genome Sequencing (WGS) and analysis of resistance-conferring mutations.

Dr. Rodwell is also an attending physician for the Refugee Health Assessment Program and co-founder of Utopia Scientific, a 501(c)(3) non-profit organization focusing on promoting awareness of the importance of science, public health and conservation through research, education and community development.

Selected Publications 

  1. Bennett RJ, Brodine S, Waalen J, Moser K, Rodwell TC. Prevalence and Treatment of Latent Tuberculosis Infection Among Newly Arrived Refugees in San Diego County, January 2010-October 2012. Am J Public Health. 2014 [epub ahead of print]. 10.2105/AJPH.2013.301637. PMCID: Pending
  2. Lin SY, Rodwell TC, Victor TC, Rider EC, Pham L, Catanzaro A, Desmond EP. Pyrosequencing for rapid detection of extensively drug-resistant Mycobacterium tuberculosis in clinical isolates and clinical specimens. J Clin Microbiol. 2014;52(2):475-82. PMCID: PMC3911348
  3. Rodwell TC, Valafar F, Douglas J, Qian L, Garfein RS, Chawla A, Torres J, Zadorozhny V, Soo Kim M, Hoshide M, Catanzaro D, Jackson L, Lin G, Desmond E, Rodrigues C, Eisenach K, Victor TC, Ismail N, Crudu V, Gle MT, Catanzaro A. Predicting Extensively Drug-resistant Tuberculosis (XDR-TB) Phenotypes with Genetic Mutations. J Clin Microbiol. 2014;52(3):781-9. PMCID: Pending
  4. Trollip A, Moore D, Coronel J, Caviedes L, Victor T, Klages S, Romancenco E, Crudu V, Rodrigues C, Ajbani K, Jackson L, Eisenach K, Garfein R, Rodwell TC, Desmond E, Groessl E, Ganiats T, Catanzaro A. Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using MODS assay. Int J Tuberc Lung Dis. 2014;18(2):227–32. PMCID: Pending
  5. Bojorquez I, Barnes RF, Flood J, Lopez-Gatell H, Garfein RS, Backer CE, Alpuche C, Vinetz JM, Catanzaro A, Kato-Maeda M, Rodwell TC. Multidrug-resistant tuberculosis among patients in Baja California, Mexico, and Hispanic patients in California. Am J Public Health. 2013;103(7):1301-5. PMCID: PMC3682598
  6. Morris MD, Quezada L, Bhat P, Moser K, Smith J, Perez H, Laniado-Laborin R, Estrada-Guzman J, Rodwell TC. Social, economic, and psychological impacts of MDR-TB treatment in Tijuana, Mexico: a patient's perspective. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2013;17(7):954-60. PMCID: PMC3769163
  7. Georghiou SB, Magana M, Garfein RS, Catanzaro DG, Catanzaro A, Rodwell TC. Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review. PLoS ONE. 2012;7(3):e33275. 10.1371/journal.pone.0033275. PMCID: PMC3315572
  8. Rodwell TC, Kapasi A, Barnes RFW, Moser K. Factors Associated with Genotype Clustering of M. tuberculosis Isolates in an Ethnically Diverse Region of Southern California, United States. Infect, Genet Evol. 2012;12(8):1917-25. PMCID: PMC3723456
  9. Shin SS, Gallardo M, Lozada R, Abramovitz D, Burgos JL, Laniado-Laborin R, Rodwell TC, Novotny TE, Strathdee S, Garfein RS. Cigarette-Smoking Intensity and Interferon-Gamma Release Assay Conversion among Persons Who Inject Drugs: A Cohort Study. Pulmonary Medicine. 2012;2012:7. PMCID: PMC3529865
  10. Yen YF, Rodwell TC, Yen MY, Shih HC, Li LH, Garfein RS. DOT associated with reduced all-cause mortality among tuberculosis patients in Taipei, Taiwan, 2006- 2008. Int J Tuberc Lung Dis. 2012;16(2):178-84. PMCID: PMC3289585
  11. Barnes RF, Moore ML, Garfein RS, Brodine S, Strathdee SA, Rodwell TC. Trends in mortality of tuberculosis patients in the United States: the long-term perspective. Ann Epidemiol. 2011;21(10):791-5. PMCID: PMC3166369
  12. Garfein RS, Laniado-Laborin R, Rodwell TC, Lozada R, Deiss R, Burgos JL, Cuevas-Mota J, Cerecer P, Moser K, Volker ML, Strathdee SA. Latent tuberculosis among persons at risk for infection with HIV, Tijuana, Mexico. Emerging Infect Dis. 2010;16(5):757-63. PMCID: PMC2953999
  13. Rodwell TC, Barnes RFW, Moore M, Strathdee SA, Raich A, Moser KS, Garfein RS. HIV–Tuberculosis coinfection in southern California: Evaluating disparities in disease burden. Am J Public Health. 2010;100(S1):S178-S85. PMCID: PMC2837460
  14. Rodwell TC, Kapasi AJ, Moore M, Milian-Suazo F, Harrise B, Guerrerod LP, Moser KS, Strathdee SA, Garfein RS. Tracing the origins of Mycobacterium bovis tuberculosis in humans in the United States to cattle in Mexico using spoligotyping. Int J Infect Dis. 2010;14S:e129–e35. PMCID: PMC2920372
  15. Rodwell TC, Robertson AM, Aguirre N, Vera A, Anderson CM, Lozada R, Chait L, Schooley RT, Zhang XQ, Strathdee SA. Pandemic (H1N1) 2009 Surveillance in Marginalized Populations, Tijuana, Mexico. Emerging Infect Dis. 2010;16(8):1292-5. PMCID: PMC3298300

Research Projects

  1. Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TB. Funding Source: NIAID R01AI105185
  2. TB Diagnostics at the Point of Care. Funding Source: NIBIB R44EB011274
  3. Rapid Tests for Drug Resistance to Detect Extensively Drug-Resistant Tuberculosis. Funding Source: NIAID U01AI082229