Sophia Georghiou

 
Sophia Georghiou, MS, is a PhD candidate in the UCSD/SDSU Joint Doctoral Program in Public Health (Global Health). Sophia earned her MS degree in Biology at the University of California, San Diego in 2010. Her Masters thesis project investigated the anthelmintic properties of the bacterial protein Cry5B against parasitic nematodes, in vivo and in vitro. While completing her degree, Sophia served as President of UCSD’s chapter of the Flying Samaritans, working with other students and local medical professionals to provide healthcare to Mexico’s underserved populations in Baja California. Upon receiving her degree, Sophia volunteered in clinics throughout Ecuador, assisting physicians and local epidemiologists in their goal of eradicating infectious diseases in the Amazon basin. The work reinforced her passion for global health research and strengthened her desire to continue her education in public health. She worked as a molecular biologist at The Scripps Research Institute in La Jolla for two years before entering into the UCSD/SDSU Joint Doctoral Program.

As a doctoral student, Sophia works with the Global Consortium for Drug-resistant TB Diagnostics (GCDD: http://gcdd.ucsd.edu) to develop and evaluate molecular diagnostics for drug-resistant TB. Sophia completed her global health practicum at Hinduja Hospital and Medical Research Center in Mumbai, India, where she led a project to evaluate the performance of a pyrosequencing platform in diagnosing drug-resistant extrapulmonary TB samples. The goal of her dissertation research is to determine the potential for molecular diagnostics to replace conventional, growth-based diagnostic methods for drug-resistant TB. Her research combines molecular methods and regression and survival analyses to analyze laboratory and clinical data from multisite, observational cohort studies. Her current research interests include bacterial drug resistance mechanisms, analysis and interpretation of diagnostic sequencing data, and the development and evaluation of molecular diagnostic technologies for infectious diseases.

In addition to her research, Sophia also enjoys teaching, and has served as a teaching assistant for genetics and HIV classes at UCSD and has accepted invitations to be a guest lecturer for global health classes at both UCSD and SDSU.

Publications:

1. Nikam C, Patel R, Sadani M, Ajbani K, Kazi M, Soman R, Shetty A, Georghiou SB, Rodwell TC, Catanzaro A, Rodrigues C (2015) Redefining MDRTBplus Test Results: What do Indeterminate Results Actually Mean?  Int J Tuberc Lung Dis. (in press)

2. Georghiou SB, Ajbani K, Rodrigues C, Rodwell TC (2015) Performance of a Pyrosequencing Platform in Diagnosing Drug-resistant Extrapulmonary Mycobacterium tuberculosis Clinical Samples in India. Int J Tuberc Lung Dis. (in press)

3. Kambli P, Ajbani K, Nikam C, Khillari A, Shetty A, Udwadia Z, Georghiou SB, Rodwell TC, Catanzaro A, Rodrigues C (2015) Determination of MICs of Levofloxacin for Mycobacterium tuberculosis with gyrA Mutations. Int J Tuberc Lung Dis. (in press)

4. Catanzaro A, Rodwell TC, Catanzaro DG, Garfein RS, Jackson RL, Seifert M, Georghiou SB, Trollip A, Groessl E, Hillery N, Crudu V, Victor TC, Rodrigues C, Lin G, Valafar F, Desmond E, Eisenach K (2015) Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-resistant Tuberculosis. PLoS ONE 10(8): e0136861.

5. Kambli P, Ajbani K, Sadani M, Nikam C, Shetty A, Udwadia Z, Georghiou SB, Rodwell TC, Catanzaro A, Rodrigues C (2015) Defining Multidrug-Resistant Tuberculosis: Correlating GenoType MTBDRplus Assay Results with Minimum Inhibitory Concentrations. Diag Microbiol Infect Dis 82(1): 49-53.

6. Georghiou SB, Magana M, Garfein RS, Catanzaro DG, Catanzaro A, et al. (2012) Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review. PLoS ONE 7(3): e33275.

7. Hu Y, Georghiou SB, Kelleher AJ, Aroian RV (2010) Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in Mice. PLoS Negl Trop Dis 4(3): e614.