Characterizing HIV and Tuberculosis Co-infection in Southern California

Funded by CHRP grant CF07-SD-302; PI: Timothy Rodwell

In San Diego County, where the TB case rate is more than twice as high as the rest of the U.S., the annual incidence of HIV/TB co-infection has remained at about 10% of all TB cases despite a decline of both TB and HIV cases in the overall population. There is a concern that the preventive measures that have proved effective in the general community are not reaching the HIV/TB patient population. 

The overall goal of this proposed project is to characterize the epidemiology of HIV and TB co-infection in San Diego and to develop an HIV/TB co-infection surveillance tool for long-term use. 

The Aims of this study are:

  1. To characterize risk factors for TB infection among HIV/TB Cases in San Diego County using a 15 year retrospective analysis.
  2. To determine the etiology of TB in HIV/TB Cases in San Diego County using genotype cluster analysis of TB isolates.
  3. To identify risk factors associated with mortality during TB treatment among HIV/TB co-infected individuals, using a 15 year retrospective analysis and a two year prospective survey.